Figure 2

Varicella and viral load in SVV BAC and WT SVV infected RMs. A and B) Representative examples of varicella in WT SVV and SVV BAC infected RMs. (A) SVV BAC infected RM on the trunk region and (B) WT SVV infected RM on the axillary region at 7dpi. SVV DNA viral load in C) skin biopsy at 10 dpi measured by quantitative PCR using primers and probe specific for SVV ORF21. Average copy number per microgram of DNA. SVV DNA viral load in D) BAL and E) whole blood was measured by quantitative PCR using primers and probe specific for SVV ORF21 from SVV BAC infected RMs (open circle) and WT SVV infected RMs (closed circle). Dashed line indicates limit of detection.