Skip to main content

Table 2 Conservation of T cell epitopes identified in the PB1 of influenza A and B viruses

From: Cross-reactive human B cell and T cell epitopes between influenza A and B viruses

Peptide locationa

Peptide sequence of influenza A PB1b

Corresponding peptide in influenza B PB1c

Amino acid identityd

Restricting allele

Reference

1-15

MDVNPTLLFLKVPAQ

*NI**YF**ID**(I/V)*

8/15

DR supertype

[54]

7-14

LLFLKVPA

F**ID**(I/V)

4/8

A2 supertype

[54]

30-38

YSHGTGTGY

*********

9/9

A1 supertype

[55]

41-49

DTVNRTHQY

***I*****

8/9

A26

[60]

92-106

MAFLEESHPGIFENS

LDRMD*E***L*QAA

5/15

DR supertype

[54]

166-174

FLKDVMESM

*CQ*IID*L

3/9

A2

[60]

238-246

RRAIATPGM

******A*I

7/9

B27

[61]

254-262

FVEALARSI

V**N**KN*

5/9

A2 supertype

[54]

257-265

TLARSICEK

N**KN***N

5/9

A3 supertype

[54]

263-271

CEKLEQSGL

**N******

8/9

B44

[54]

316-330

RMFLAMITYITRNQP

*I****TER***DS*

9/15

DR supertype

[54]

347-355

KMARLGKGY

*I******F

7/9

B62

[60]

349-357

ARLGKGYMF

******F*I

7/9

B27

[60]

357-364

FESKSMKL

IT**TKR*

3/8

B44

[54]

404-418

SPGMMMGMFNMLSTV

***************

15/15

DR supertype

[54]

407-415

MMMGMFNML

*********

9/9

A2 supertype

[54]

408-422

MMGMFNMLSTVLGVS

**************A

14/15

DR supertype

[54]

412-421

FNMLSTVLGV

**********

10/10

A2 supertype

[54]

413-421

NMLSTVLGV

**********

9/9

A*0201

[39]

471-480

KLVGINMSKK

**L*(*/V)*****

8~9/10

A3 supertype

[55]

488-497

GTFEFTSFFY

*M*****M**

8/10

A3 supertype

[55]

489-497

TFEFTSFFY

M*****M**

7/9

A1 supertype

[54]

490-497

FEFTSFFY

*****M**

7/8

B44

[54]

496-505

FYRYGFVANF

***D***S**

8/10

A24 supertype

[55]

501-509

FVANFSMEL

**S**A**(*/I)

6~7/9

A2 supertype

[54]

505-514

FSMELPSFGV

*A**(*/I)*****

8~9/10

A2 supertype

[54]

509-517

LPSFGVSGI

(*/I)*****A*V

6~7/9

B7

[54]

540-548

GPATAQMAL

******T*I

7/9

B7

[60]

566-574

TQIQTRRSF

SKVEGK*MK

1/9

B62

[60]

590-599

LVSDGGPNLY

**A*****I*

8/10

A1 supertype

[55]

591-599

VSDGGPNLY

*A*****I*

7/9

A1

[62]

741-749

AEIMKICST

EKA*AHLGE

1/9

B44

[54]

21-38

TFPYTGDPPYSHGTGTGY

******V***********

17/18

CD8

[63]

43-60

VNRTHQYSEKGKWTTNTE

*I***E**N***QY(I/V)SD(V/I)

9/18

?

[63]

57-73

TNTETGAPQLNPIDGPL

(I/V)SD(V/I)**CTM(V/I)D*TN***

6/17

?

[63]

64-82

PQLNPIDGPLPEDNEPSGY

(T/A/V)MVD*TN**********A*

12/19

?

[63]

86-103

DCVLEAMAFLEESHPGIF

******LDRMD*E***L*

11/18

?

[63]

123-140

TQGRQTYDWTLNRNQPAA

******F***VC******

15/18

?

[63]

270-287

GLPVGGNEKKAKLANVVR

*************S*A*A

15/18

?

[63]

316-333

RMFLAMITYITRNQPEWF

*I****TER***DS*I**

11/18

?

[63]

395-428

LLIDGTASLSPGMMMGMFNMLSTVLGVSILNLGQ

FNEE***********************AA*GIKN

24/34

?

[64]

402-419

SLSPGMMMGMFNMLSTVL

******************

18/18

CD4

[63]

410-426

GMFNMLSTVLGVSILNL

************AA*GI

13/17

?

[63]

417-433

TVLGVSILNLGQKRYTK

*****AA*GIKNIGNKE

6/17

CD4

[63]

432-449

TKTTYWWDGLQSSDDFAL

GNKE*L************

13/18

CD4

[63]

447-463

FALIVNAPNYAGIQAGV

***F***KDE*TCME*I

8/17

?

[65]

470-486

CKLVGINMSKKKSYINR

***L*(*/V)********C*E

13~14/17

?

[63]

498-514

RYGFVANFSMELPSFGV

*D***S**A**(*/I)*****

13~14/17

CD8

[63]

505-521

FSMELPSFGVSGINESA

*A**(*/I)*****A*V****

13~14/17

?

[63]

548–564

LQLFIKDYRYTYRCHRG

I****A******K****

14/17

?

[65]

562-579

HRGDTQIQTRRSFELKKL

****SKVEGK*MKII*E*

7/18

?

[63]

705-722

YRRPVGISSMVEAMVSRA

**K***QH**L***AH*L

11/18

CD8

[63]

  1. aBased on the PB1 of A/Puerto Rico/8/34(H1N1) (NP_040985).
  2. bAmino acid sequence in the original publication.
  3. cB/Wisconsin/01/2010 (B/Yamagata/16/88-lineage) and B/Brisbane/60/2008 (B/Victoria/2/87-like lineage).
  4. dEmbolden when all amino acids are identical or when the observed amino acid variation in B viruses does not decrease the SYFPEITHI binding score (http://www.syfpeithi.de/bin/MHCServer.dll/EpitopePrediction.htm).
Back to article page

Virology Journal

ISSN: 1743-422X