Figure 1
From: Bioenergetics of murine lungs infected with respiratory syncytial virus
Lung respiration in RSV-infected and uninfected BALB/c mice. (A) A representative run of O2 consumption by lung specimen (26 mg) from infected mouse on day 6. The rate of O2 consumption, k, was set as the negative of the slope of [O2] vs. t (1.4 μM O2 min-1). The value of k after the addition of 10 μM NaCN was 0.3 (78% inhibition), confirming the oxidation occurred mainly in the respiratory chain. Glucose oxidase (catalyzes the reaction of D-glucose + O2 to D-glucono-δ-lactone + H2O2) depleted remaining O2 in the solution. (B) The values of k c (μM O2 min-1 mg-1) for all experiments are plotted as a function of days after inoculation with RSV strain A2 (infected, I) or mock preparation of HEp-2 culture supernatant (uninfected, U). “n” represents number of mice. The data represent at least 10 independent experiments.