Figure 3

MP10 replication causes severe necrotizing myositis in the skeletal muscle tissues of mice. The pathology and viral distribution in tissues of MP10-infected mice (from 3 d.p.i. to 9 d.p.i., n = 6) were observed by HE stain (left panel) and IHC (right panel). Representative images from the rear limb muscle, sternocleidomastoid muscle, and intercostal muscle at 5 d.p.i. are shown, and the positions of lesions and viral antigens are denoted with solid and open arrows, respectively. The results of mock-infection were used as control. Magnification: 100 ×.