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Figure 3 | Virology Journal

Figure 3

From: Inhibition of hepatitis B virus (HBV) gene expression and replication by HBx gene silencing in a hydrodynamic injection mouse model with a new clone of HBV genotype B

Figure 3

HBV persistence after HI in mouse in dependence on the mouse genetic backgrounds and the vector backbones. 10 μg of pBS-HBV1.3B or pAAV-HBV1.3B were injected into the tail veins of BALB/c or C57BL/6 mice. Each group included 5 mice. In addition, 10 μg pAAV-HBV1.3B or pAAV-HBV1.2 were injected into the tail veins of C57BL/6 mice to test the ability of these two plasmids to establish persistent HBV replication. pAAV-HBV1.3B group included 14 mice and pAAV-HBV1.2 group included 9 mice. (A) The positive rate for serum HBsAg in C57BL/6 or BALB/c mice receiving pBS-HBV1.3B or pAAV-HBV1.3B injections at indicated time points after injection. The data were analyzed by Kaplan–Meier analysis, and the differences between each group were statistically significant (p = 0.004, <0.05). (B) The positive rate for serum HBsAg in C57BL/6 mice receiving pAAV-HBV1.3B or pAAV-HBV1.2 injection. The data were analyzed by Kaplan–Meier analysis, and the differences between two groups were statistically significant (p = 0.017, <0.05). The cutoff value for determining HBsAg-positivity was 0.1.

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Virology Journal

ISSN: 1743-422X