Table 2 Intersecting pathways and proteins between HIV dementia and classical neurodegenerative diseases in humans

Glycolysis/ Gluconeogenesis pathway

387

P09972

Fructose-bisphosphate aldolase C [Homo sapiens]

1.69

0.0009

Schizophrenia, bipolar disorder, and depression [131]

471

P00338

L-lactate dehydrogenase A chain [Homo sapiens]

1.5

0.039

439

P07195

L-lactate dehydrogenase B chain (LDH) [Homo sapiens]

1.43

0.028

412

P14550

Alcohol dehydrogenase [NADP+][Homo sapiens]

1.36

0.028

605

P60174

Triosephosphate isomerase [Homo sapiens]

−1.32

0.02

Neurodegeneration [132]

581

Q53G35

Phosphoglycerate mutase 1 (Brain) variant (Fragment) [Homo sapiens]

−1.6

0.043

AD [133]

Oxidative phosphorylation pathway

518

B3KP20

cDNA FLJ30970 fis, clone HEART2000444, highly similar to Homo sapiens phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP), mRNA [Homo sapiens]

1.57

0.043

AD [134]

522

P36543

V-type proton ATPase subunit E 1 [Homo sapiens]

1.55

0.0068

658

O75947-2

(ATP5H)Isoform 2 of O75947. [Homo sapiens]

1.48

0.015

587

P47985

Cytochrome b-c1 complex subunit Rieske, mitochondrial[Homo sapiens]

1.38

0.013

634

O96000

NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10 [Homo sapiens]

−1.42

0.0059

Nitrogen metabolism pathway

363

P15104

Glutamine synthetase[Homo sapiens]

1.85

0.0007

AD[135]

578

P00918

Carbonic anhydrase 2 [Homo sapiens]

−3.11

0.009

Mental retardation,

AD [136, 137]

Arachidonic acid metabolism pathway

494

P16152

Carbonyl r Carbonyl reductase [NADPH] 1 [Homo sapiens]

2

0.014

AD [138]

Purine metabolism pathway

787

P22392

Nucleoside diphosphate kinase B [Homo sapiens]

−1.33

0.0061

DS, AD [139]

Arginine and proline metabolism pathway

369

P12532

Creatine kinase, ubiquitous mitochondrial [Homo sapiens]

1.47

0.0006

Alzheimer’s and Pick’s disease [140]

Glutathione metabolism pathway

624

P09211

Glutathione S-transferase P [Homo sapiens]

−1.64

0.024

Parkinson’s disease, AD [141, 142]

MAPK signalling pathway

738

P16949

Stathmin [Homo sapiens]

1.48

0.031

DS and AD [143, 144]

608

P62993

Growth factor receptor-bound protein 2 [Homo sapiens]

1.29

0.04

AD [145]

Calcium signalling pathway

496

B4DKM5

cDNA FLJ60120, highly similar to Voltage-dependent anion-selective channel protein 2 [Homo sapiens]*

1.57

0.021

411

P50148

Guanine nucleotide-binding Protein G(o) subunit alpha [Homo sapiens]

1.36

0.026

Familial Alzheimer’s disease [146]

Axon guidance pathway

230

Q16555

Dihydropyrimidinase-related protein 2 [Homo sapiens]

1.57

0.025

AD[147]

Parkinson's disease pathway

384

Q7KYV2

H5 [Homo sapiens]*

1.37

0.035

Autosomal-recessive juvenile parkinsonism [148]

Antigen processing and presentation pathway

189

P11142

Heat shock cognate 71 kDa protein [Homo sapiens]

1.39

0.022

AD [149]

N/A

393

O00154

(ACOT7)Isoform 6 of O00154. [Homo sapiens]

1.64

0.0018

394

Q2TU84

Aspartate aminotransferase [Homo sapiens]

1.51

0.0048

350

P49411

Elongation factor Tu, mitochondrial [Homo sapiens]

1.35

0.008

Infantile Encephalopathy [150]

723

P61601

Neurocalcin-delta [Homo sapiens]*

1.57

0.043

AD [151]

475

B4DGP9

cDNA FLJ54102, highly similar to Beta-soluble NSF attachment protein [Homo sapiens]

1.53

0.033

458

P62879

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [Homo sapiens]

1.73

0.0089

AD [152]

784

A8MVL5

Putative uncharacterized protein PRDX5 [Homo sapiens]

−1.88

0.032

AD and parkinson [153, 154]