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Figure 8 | Virology Journal

Figure 8

From: A novel platform for virus-like particle-display of flaviviral envelope domain III: induction of Dengue and West Nile virus neutralizing antibodies

Figure 8

Immunoreactivity of VLP-displayed DIII. (A), Aliquots of control VLPs devoid of DIII (VLP-0) or VLPs pseudotyped with DIII-DENV1-RIgE (VLP-DENV1) were coated on plates and probed by ELISA for reactivity towards two different samples of patient sera positive for DENV1 infection. (B), Aliquots of control VLP-0 or VLPs pseudotyped with DIII-WNVKun-RIgE (VLP-WNVKun) were tested by ELISA for reactivity towards two different types of anti-WNV DIII antibodies, mouse monoclonal 3.67G and rabbit polyclonal (PC) anti-WNV DIII antibodies. (C), Dose-dependent reactivity of VLP-DENV1 with DENV1-specific patient antibodies. Data presented are mean ± SEM, n = 4; (*), significantly different at p < 0.05 level.

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Virology Journal

ISSN: 1743-422X