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Table 2 The amino acid substitutions in the HA2 and character of Stachyflin-resistant (R) virus clones

From: Antiviral activity of stachyflin on influenza A viruses of different hemagglutinin subtypes

Virus EC50(μM) Amino acid position in HA2a pHc
    37 51 85 91 98 107 110  
WSN Wild type 0.02 D K D I L T F 0.0
  R1 >6.50 N -b - - - - - 0.3
  R2 >6.50 - R - - - - - −0.3
  R3 >6.50 - - H - - - - 0.0
  R4 >6.50 - - - - - I - 0.2
  R5 >6.50 - - - - V - - −0.2
  R6 >6.50 - - - F - - - 0.0
PR8 Wild type 0.49 D K D I L T F N.D.d
  R1 >6.50 - - - - S - - N.D.
  R2 >6.50 - - - - - - S N.D
Ibaraki Wild type 0.17 D K D I L T F N.D
  R1 >6.50 - R - - - - - N.D.
Taiwan Wild type 0.44 D K D I L T F N.D.
  R1 >6.50 - R - - - - - N.D.
  1. a H3 subtype numbering.
  2. b Dash (-) means the same amino acid as the wild type virus.
  3. c The pH at which 50% hemolysis of the wild type virus is 6.0. The values indicate the difference of the pH at which 50% hemolysis between the Stachyflin-resistant virus clones and wild type virus.
  4. d Not determined.