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Table 1 Expression of Chemokine Receptors, Chemokines and Cytokines in Leukocyte Populations

From: Persistent expression of chemokine and chemokine receptor RNAs at primary and latent sites of herpes simplex virus 1 infection

Chemokine receptors Cell type expression Chemokine ligand Proposed primary function(s)
CCR1 T cells, macrophages, immature dendritic cells (DC), natural killer cells (NK) RANTES; MIP-1α; MCP-3, and 4; HCC-1, 2, and 4 Migration of DC to sites of inflammation Recruitment of T cells, macrophages and NK
CCR2 T cells, natural killer cells (NK), macrophages, immature DC MCP-1, 3, and 4 Migration of effector T cells (Th1) Migration of DC progenitors to sites of inflammation
CCR3 eosinophils, basophils, T cells eotaxin-1 and 2; RANTES; MCP-2, 3, and 4; HCC-2 Recruitment of eosinophils
CCR5 T cells (Th1, Tc1), macrophages, immature DC RANTES; MIP-1α and 1β Migration of effector T cells (Th1) Migration of DC to sites of inflammation Recruitment of macrophages
CCR6 immature DC (CD34+/Langerhans-like), T cells MIP-3α Migration of DC to skin
CCR7 T cells, B cells, mature DC SLC, ELC Migration of naïve T cells to lymph nodes Migration of memory T cells to lymphoid tissue
    Migration of B cells Migration of DC to lymphoid tissues
CXCR3 T cells (Th1, Tc1) IP-10, MIG, ITAC Migration of effector T cells (Th1)
CXCR4 T cells, macrophages, DC, B cells, others including neurons SDF-1 Migration of effector T cells (Th2)
    Migration of B cells
    Migration of hematopoietic progenitors
Chemokines   Receptor  
MIP-1α T cells, NK, macrophages, others CCR1, CCR5 Chemoattract macrophages, T cells, NK, and others
MIP-1β T cells, NK, macrophages, others CCR5, CCR1 (weak) Chemoattract macrophages, T cells, and others
RANTES T cells, NK CCR1, CCR5, CCR3 (weak) Chemoattract T cells and others
MCP-1 macrophages, others CCR2 Chemoattract macrophages, T cells, NK, and others
Eotaxin-1 epithelial cells, NK, macrophages, others CCR3 Chemoattract eosinophils
Cytokines   Receptor  
IFN-γ T cells, NK IFN-γR Activation of antiviral response
TNF-α macrophages, NK, others TNF-R Broad activation of antiviral and inflammatory response