Table 1 Expression of Chemokine Receptors, Chemokines and Cytokines in Leukocyte Populations

CCR1

T cells, macrophages, immature dendritic cells (DC), natural killer cells (NK)

RANTES; MIP-1α; MCP-3, and 4; HCC-1, 2, and 4

Migration of DC to sites of inflammation Recruitment of T cells, macrophages and NK

CCR2

T cells, natural killer cells (NK), macrophages, immature DC

MCP-1, 3, and 4

Migration of effector T cells (Th1) Migration of DC progenitors to sites of inflammation

CCR3

eosinophils, basophils, T cells

eotaxin-1 and 2; RANTES; MCP-2, 3, and 4; HCC-2

Recruitment of eosinophils

CCR5

T cells (Th1, Tc1), macrophages, immature DC

RANTES; MIP-1α and 1β

Migration of effector T cells (Th1) Migration of DC to sites of inflammation Recruitment of macrophages

CCR6

immature DC (CD34+/Langerhans-like), T cells

MIP-3α

Migration of DC to skin

CCR7

T cells, B cells, mature DC

SLC, ELC

Migration of naïve T cells to lymph nodes Migration of memory T cells to lymphoid tissue

Migration of B cells Migration of DC to lymphoid tissues

CXCR3

T cells (Th1, Tc1)

IP-10, MIG, ITAC

Migration of effector T cells (Th1)

CXCR4

T cells, macrophages, DC, B cells, others including neurons

SDF-1

Migration of effector T cells (Th2)

Migration of B cells

Migration of hematopoietic progenitors

Chemokines

Receptor

MIP-1α

T cells, NK, macrophages, others

CCR1, CCR5

Chemoattract macrophages, T cells, NK, and others

MIP-1β

T cells, NK, macrophages, others

CCR5, CCR1 (weak)

Chemoattract macrophages, T cells, and others

RANTES

T cells, NK

CCR1, CCR5, CCR3 (weak)

Chemoattract T cells and others

MCP-1

macrophages, others

CCR2

Chemoattract macrophages, T cells, NK, and others

Eotaxin-1

epithelial cells, NK, macrophages, others

CCR3

Chemoattract eosinophils

Cytokines

Receptor

IFN-γ

T cells, NK

IFN-γR

Activation of antiviral response

TNF-α

macrophages, NK, others

TNF-R

Broad activation of antiviral and inflammatory response