The matrix (M) protein of newcastle disease virus binds to human bax through its BH3 domain

Table 2 Viral proteins that resemble Bcl-2 family members by having one or more BH-like domains.

Name	Viral Protein	Function	Interacts With	Does Not Interact With	Annotation	Reference
Vaccinia Virus	FL1	Anti-apoptotic	Bax, Bak, Bim	-	BH3 Domain	[29, 45]
HCV	Core protein	Pro-apoptotic	Mcl-1	Bcl-XL, Bcl-w	BH3 Domain	[46]
Epstein-Barr Virus	BHRF1	Anti-apoptotic	Bax, Bak, Bim	-	BH3 Binding Groove	[21, 22, 47]
Gamma-Herpes Virus 68	M11, vBcl-2	Anti-apoptotic	Bim	-	-	[40, 48]
Myxoma Virus	M11L	Anti-apoptotic	Bak	-	BH3 Domain	[49]
African Swine Virus	A179L, 5-HL	Anti-apoptotic	Bid, Bax, Bak, Noxa	-	BH1 Domain	[23, 41]
Kaposi Sarcoma-Associated Virus	ORF K12	Anti-apoptotic	-	Bak, Bax	Human Herpesvirus-8. 9 Homologs	[24, 25, 50]
HBV	HBSP	Pro-apoptotic	-	-	BH3 Domain	[51]
Herpesvirus Saimiri	ORF16	Anti-apoptotic	Bax, Bak	-	Conserved BH1, BH2. No BH3	[26, 52]
Orf Virus	ORFV125	Anti-apoptotic	Bik, Puma, Noxa, Bim	Inactive form of Bax	BH3 Domain	[53]
Adenovirus	E1B-19K	Anti-apoptotic,	Bax	Bcl-2	BH3 Domain	[28]

So far only few viral proteins discovered show pro-apoptotic characteristics compared to the rest with anti-apoptotic effects.

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