Fig. 4

Predictive ability of clinical scores and inflammatory markers for 28-day mortality in COVID-19 patients. (A) Receiver Operating Characteristic (ROC) curves for different clinical prediction scores in predicting 28-day mortality in COVID-19 patients. The area under the curve (AUC) for sSOFA was 0.627 (95% confidence interval [CI]: 0.508–0.746), eSOFA, AUC was 0.831 (95% CI: 0.761–0.900); qSOFA, AUC was 0.889 (95% CI: 0.823–0.955); SOFA, AUC was 0.802 (95% CI: 0.705–0.900); NEWS2, AUC was 0.871 (95% CI: 0.808–0.934); PSI risk class, AUC was 0.846 (95% CI: 0.737–0.954); PSI, AUC was 0.878 (95% CI: 0.773–0.984); COVID-GRAM, AUC was 0.841 (95% CI: 0.730–0.953); CURB-65, AUC was 0.897 (95% CI: 0.817–0.978). (B) ROC curves for different laboratory inflammatory markers in predicting 28-day mortality in COVID-19 patients. PCT, AUC was 0.768 (95% CI: 0.670–0.866); CRP, AUC was 0.781 (95% CI: 0.685–0.878); NLR, AUC was 0.677 (95% CI: 0.546–0.808); MLR, AUC was 0.619 (95% CI: 0.488–0.750); PLR, AUC was 0.612 (95% CI: 0.480–0.743); LCR, AUC was 0.812 (95% CI: 0.716–0.907); CAR, AUC was 0.798 (95% CI: 0.706–0.890); SIRI, AUC was 0.628 (95% CI: 0.492–0.764); SII, AUC was 0.644 (95% CI: 0.513–0.775). Abbreviations TPR: true positive rate; FPR: false positive rate; s, e, q SOFA, simplified, early, quick sequential organ failure assessment; NEWS2, National Early Warning Score 2; PSI, Pneumonia Severity Index; PCT, Procalcitonin; CRP, C-reactive protein; NLR, Neutrophil-to- lymphocyte ratio; MLR, Monocyte-to-lymphocyte ratio; PLR, Platelet-to-lymphocyte ratio; LCR, Lymphocyte-to-C-reactive protein ratio; CAR, C-reactive protein-to-albumin ratio; SIRI, Systemic inflammation response index; SII: Systemic inflammation index. SIRI = (Neutrophil count × Monocyte count) / Lymphocyte count; SII = (Neutrophil count × Platelet count) / Lymphocyte count