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Table 1 Recombinant viruses with SARS-CoV-2 RDB fragments incorporated into HA molecule

From: Expression of the SARS-CoV-2 receptor-binding domain by live attenuated influenza vaccine virus as a strategy for designing a bivalent vaccine against COVID-19 and influenza

Virus name

Type of insert

Viral titer in eggs, lgEID50/mL

Genetic stability of the inserta

LAIV

-

9.8

-

FluCoVac-19

RBD 194

8.4*

A single mutation in the (G4S)2 linker

FluCoVac-20

RBD 223

8.3*

A single mutation in the (G4S)2 linker

  1. agenetic stability was assessed after 10 passages in eggs
  2. *Significantly reduced titer (p<0.05) compared to the LAIV vector control virus
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Virology Journal

ISSN: 1743-422X