Fig. 2

DDX5 interactome in mock and SINV-infected cells. A, B and D Volcano plots showing the global protein enrichment in A mock-DDX5-IP versus mock-IgG-IP, B SINV-DDX5-IP versus SINV-IgG-IP and D SINV-DDX5-IP versus mock-DDX5-IP using data from three independent replicates. The cells were infected with SINV-GFP during for 24 h at an MOI 0.1. Significantly enriched or depleted proteins are represented in red or blue, respectively. Cut off values: FDR < 1%, at least 5 spectral counts in the most abundant condition, fold change > 2, adjusted p-value lower than 0.05. Viral proteins and selected host proteins are circled in black and orange, respectively. C Venn diagram showing the number of overlapping and unique significantly enriched proteins identified in DDX5 IP compared to IgG in mock and SINV infected proteomic analyses