| Position 22 (n = 29) | P value | Position 41 (n = 27) | P value | Position 45 (n = 30) | P value | Position 55 (n = 28) | P value | |||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Amino acid | I | L | Â | G | N | S | Â | Y | H | Â | A | T | Â |
N (%) | 16 (55%) | 13 (45%) | - | 15 (55%) | 6 (22%) | 6 (22%) | - | 18 (60%) | 12 (40%) | - | 7 (25%) | 21 (75%) | - |
Age in years, mean (SD) | 47.31 (6.23) | 49.08 (8.43) | 0.523 | 47.47 (4.9) | 46.83 (7.6) | 45.7 (8.7) | 0.822/ 0.548 | 48.44 (6.5) | 48.1 (8.4) | 0.895 | 49.43 (6.6) | 47.57 (6.6) | 0.525 |
Sex, female N (%) | 10 (63%) | 11 (85%) | 0.624 | 10 (67%) | 5 (83.3%) | 4 (6707%) | 0.733 | 15 (83%) | 9 (75%) | 0.576 | 7 (64%) | 27 (84%) | 0.145 |
CD4 +, mean (SD) | 274.50 (119.21) | 313.71 (139.52) | 0.662 | 272.2 (191) | 213.7 (74.2) | 367 (222.6) | 0.564/ 0.513 | 287.71 (164.3) | 241. 8 (125.4) | 0.535 | 150.5 (72.8) | 330.92 (152) | 0.132 |
Body Mass index (BMI) | 235.5 (16) | 223 (34) | 0.532 | 22.3 (3.4) | 23 (8.4) | 21.5 (2.5) | 0.747/ 0.640 | 23 (4.8) | 23.5 (5.8) | 0.811 | 20.5 (4) | 24.2 (5.4) | 0.118 |
Smoker | 9 (56%) | 7 (64%) | 0.701 | 7 (47%) | 3 (50%) | 6 (100%) | 0.167 | 9 (56%) | 8 (67%) | 0.576 | 6 (86%) | 11 (55%) | 0.148 |
Alcohol use | 9 (56%) | 5 (45%) | 0.581 | 6 (40%) | 2 (33%) | 5 (83%) | 0.253 | 7 (44%) | 6 (50%) | 0.743 | 3 (42%) | 11 (55%) | 0.580 |
Locality, rural N (%) | 6 (38%) | 9 (69%) | 0.089 | 10 (67%) | 4 (67%) | 3 (50%) | 0.757 | 10 (56%) | 7 (58%) | 0.880 | 4 (57%) | 11 (52%) | 0.827 |
Trp, ug/mL | 0.16 (0.06) | 0.13 (0.07) | 0.223 | 0.17 (0.07) | 0.13 (0.08) | 0.13 (0.04) | 0.303/ 0.226 | 0.15 (0.07) | 0.15 (0.06) | 0.710 | 0.15 (0.07) | 0.15 (0.06) | 0.822 |
Kyn, ug/mL | 0.0087 (0.003) | 0.0088 (0.003) | 0.904 | 0.01 (0.002) | 0.01 (0.003) | 0.008 (0.004) | 0.587/ 0.254 | 0.009 (0.002) | 0.009 (0.001) | 0.646 | 0.009 (0.003) | 0.008 (0.003) | 0.589 |
Kyn/Trp ratio | 0.062 (0.027) | 0.085 (0.042) | 0.106 | 0.07 (0.034) | 0.089 (0.045) | 0.0586 (0.032) | 0.290/ 0.418 | 0.068 (0.036) | 0.071 (0.032) | 0.739 | 0.074 (0.038) | 0.061 (0.026) | 0.375 |
QUIN, ug/mL | 0.0013 (0.0009) | 0.0015 (0.0009) | 0.543 | 0.0017 (0.0009) | 0.0013 (0.0004) | 0.0009 (0.0007) | 0.368/.073 | 0.0016 (0.0009) | 0.0012 (0.0007) | 0.157 | 0.002 (0.0012) | 0.001 (0.0005) | 0.022 |
KA, ug/mL | 0.000014 (00002) | 0.00002 (0.00003) | 0.115 | 0.00003 (0.00003) | 0.000008 (0.00003) | 0.000007 (0.00003) | 0.076/ 0.126 | 0.00002 (0.00003) | 0.00001 (0.00001) | 0.725 | 0.00001 (0.00001) | 0.00002 (0.00003) | 0.666 |