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Table 1 Affinity of mAbs determined by ELISA

From: Novel neutralizing SARS-CoV-2-specific mAbs offer detection of RBD linear epitopes

mAb Name

[Ag]

(μg/ml)

OD-50*

Average

Kaff (M-1)

2B4-G11

8.0

4.0

2.0

1.0

1.0965

1.078

1.0545

0.99

4.4×108

1D9-D1

8.0

4.0

2.0

1.0

0.988

0.987

0.9495

0.92

6.4×108

1G1-G9

8.0

4.0

2.0

1.0

0.9495

0.923

0.9195

0.8355

1.87×109

2E7-D2

2.0

1.0

0.5

0.25

0.894

0.866

0.8805

0.8295

1.139×1010

2B4-G8

0.0312

0.0156

0.0078

0.0039

0.721

0.697

0.694

0.586

2.43×1010

  1. *OD-50 represents the half maximum optical density obtained for a given concentration of rRBD ([Ag]) and the corresponding mAb ([Ab]). The affinity constant (Kaff) for each selected concentration of Ag and Ab was calculated using the formula described in the Methods
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Virology Journal

ISSN: 1743-422X