Virology Journal

Table 1 Structural alignment of different species root mean square derivation score (R.M.S.D.) and homology model comparison for either whole reverse transcriptase structure, nucleoside reverse transcriptase inhibitor (NRTIs) binding site (active site), or non-nucleoside reverse transcriptase inhibitor (NNRTIs) binding site (allosteric site)

From: HTLV-1 reverse transcriptase homology model provides structural basis for sensitivity to existing nucleoside/nucleotide reverse transcriptase inhibitors

	1jla	alpha	4mh8	7sr6
Whole structure
1jla	100
alpha	4.282	100
4mh8	10.225	0.109	100
7sr6	3.956	3.936	11.075	100
Allosteric
1jla	100
alpha	4.765	100
4mh8	1.847	0.083	100
7sr6	3.494	2.559	1.554	100
Active
1jla	100
alpha	5.03	100
4mh8	2.563	1.3464	100
7sr6	4.746	4.332	4.244	100

	Phyre²	alpha	Swiss	Mod
Whole structure
Phyre²	100
alpha	3.109	100
Swiss	3.601	1.909	100
Mod	3.853	2.081	2.488	100
Allosteric site
Phyre²	100
alpha	1.109	100
Swiss	1.466	1.552	100
Mod	1.782	1.407	1.611	100

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ISSN: 1743-422X

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