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Fig. 6 | Virology Journal

Fig. 6

From: The artificial amino acid change in the sialic acid-binding domain of the hemagglutinin neuraminidase of newcastle disease virus increases its specificity to HCT 116 colorectal cancer cells and tumor suppression effect

Fig. 6

The susceptibility of colorectal cancer cells to rNDV or S519G mutant rNDV infections. MTT assays of rNDV and S519G mutant rNDV on colorectal cancer cells (HCT 116 and HT-29) colorectal normal cells (CCD-18Co), and various cancer cells (T98G; glioblastoma, A549; lung cancer). Before one day, the cells were cultured in 96-well tissue culture plates and infected with several titers (1 MOI) of rNDV or S519G mutant rNDV viruses. For negative control, the cells were grown in a culture medium. At 96 h post-infection, MTT assays were performed Cell Proliferation Assay kit. (n = 4, error bar: SEM, *p < 0.05, **p < 0.01, ***p < 0.001 determined by the Student’s t-test). MOI; multiplicity of infection, rNDV; recombinant NDV

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Virology Journal

ISSN: 1743-422X