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Fig. 5 | Virology Journal

Fig. 5

From: The artificial amino acid change in the sialic acid-binding domain of the hemagglutinin neuraminidase of newcastle disease virus increases its specificity to HCT 116 colorectal cancer cells and tumor suppression effect

Fig. 5

Cytopathic effect (CPE) in various cancer cells with S519G mutant rNDV virus. S519G mutant rNDV virus was infected in colorectal cancer cells (HCT 116 and HT-29), colorectal normal cells (CCD-18Co), and various cancer cells (T98G; glioblastoma, A549; lung cancer) at an MOI of 1. At 48 h post infection, there was no CPE in CCD-18Co, but CPE was observed in HCT 116 to form syncytia, HT-29 cells. In addition, the rNDV infection group was showed significant CPE in A519 cells but comparatively not in S519G mutant rNDV. rNDV; recombinant NDV

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Virology Journal

ISSN: 1743-422X