Table 3 List of COVID-19 vaccine candidates
From: An overview on the treatments and prevention against COVID-19
Type of candidate vaccine | Vaccine platform | Company/University | Vaccine characteristics/immunogen |
|---|---|---|---|
ARCT-154 | RNA | Arcturus Therapeutics | Self-replicating mRNA coding spike protein, encapsulated in lipid nanoparticles |
Inactivated SARS-CoV-2 vaccine (Vero cell) | Inactivated virus | Beijing Minhai Biotechnology Co | Inactivated SARS-CoV-2 |
WIBP COVID-19 vaccine | Inactivated virus | Sinopharm; China National Biotec Group Co; Wuhan Institute of Biological Products | Inactivated SARS-CoV-2 |
Inactivated SARS-CoV-2 vaccine (Vero cell), vaccine name BBIBP-CorV | Inactivated virus | Sinopharm; China National Biotec Group Co; Wuhan Institute of Biological Products, Beijing Institute of Biological Products | Inactivated SARS-CoV-2 |
SARS-CoV-2 rS/Matrix M1-Adjuvant | Protein subunit | Novavax | Full-length recombinant SARS CoV-2 |
BNT162b2 (3 LNP-mRNAs), also known as "Comirnaty" | RNA | Pfizer/BioNTech + Fosun Pharma | RNA based vaccine |
Recombinant SARS-CoV-2 vaccine (CHO Cell) Zifivax (ZF2001) | Protein subunit | Anhui Zhifei Longcom Biopharmaceutical + Institute of Microbiology, Chinese Academy of Sciences Zhongyianke Biotech | Recombinant spike protein |
CVnCoV Vaccine | RNA | CureVac AG | RNA based vaccine |
SARS-CoV-2 vaccine (vero cells) | Inactivated virus | Institute of Medical Biology + Chinese Academy of Medical Sciences | Inactivated SARS-CoV-2 |
MVC-COV1901 | Protein subunit | Medigen Vaccine Biologics + Dynavax + National Institute of Allergy and Infectious Diseases (NIAID) | Spike-2P protein + adjuvant CpG 1018 |
CIGB-66 | Protein subunit | Center for Genetic Engineering and Biotechnology (CIGB) | RBD + aluminium hydroxide |
Recombinant protein vaccine S-268019 | Protein subunit | Shionogi | using Baculovirus expression vector system |
TURKOVAC | Inactivated virus | Erciyes University and the Health Institutes of Turkey (TUSEB) | Inactivated SARS-CoV-2 |
Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01) | Protein subunit | Livzon Pharmaceutical | Recombinant spike protein |
Noora Vaccine | Protein subunit | Bagheiat-allah University of Medical Sciences/AmitisGen | RBD protein recombinant SARS-CoV-2 vaccine |
COVID-19 Vaccine Hipra | Protein subunit | Laboratorios Hipra, S.A | Recombinant protein RBD fusion dimer adjuvanted vaccine |
SCTV01C | Protein subunit | Sinocelltech Ltd | A Bivalent Recombinant Trimeric S Protein vaccine against SARS-CoV-2 Variants |
CoviVac | Inactivated virus | Chumakov Federal Scientific Center for Research and Development of Immune-and-Biological Products | Inactivated Whole Virion Concentrated Purified Vaccine |
Omicron COVID-19 inactivated Vaccine (Vero Cell) | Inactivated virus | China National Biotec Group Company Limited | Inactivated SARS-CoV-2 |
MV C-COV1901 | Protein subunit | Medigen Vaccine Biologics/Dynavax/NIAID | Spike protein with aluminum and CpG 1018 as adjuvant |
DelNS1-2019-nCoV-RBD-OPT1 | Viral vector (Replicating) | University of Hong Kong, Xiamen University and Beijing Wantai Biological Pharmacy | Intranasal flu-based-RBD |
COVAX-19 | Protein subunit | Vaxine Pty Ltd | Recombinant spike protein with Advaxâ„¢ adjuvant |
Razi Cov Pars | Protein subunit | Razi Vaccine and Serum Research Institute | Recombinant spike protein |
Recombinant SARS-CoV-2 Fusion Protein Vaccine (V-01) | Protein subunit | Guangdong Provincial Center for Disease Control and Prevention/Gaozhou Center for Disease Control and Prevention | Recombinant spike protein |
GRAd-COV2 | Viral vector (Non-replicating) | ReiThera/Leukocare/Univercells | Replication-defective Gorilla Adenovirus vector-based vaccine, which codes spike protein |
VXA-CoV2-1 | Viral vector (Non-replicating) | Vaxart | Ad5 vector-based vaccine that expresses a SARS-CoV-2 antigen and a dsRNA adjuvant to increase immunogenicity, which given orally |
COVI-VAC | Live attenuated virus | Codagenix/Serum Institute of India | Live attenuated SARS-CoV-2 |
ChulaCov19 | RNA | Chulalongkorn University | mRNA vaccine |
BBV154 | Viral vector (Non-replicating) | Bharat Biotech International Limited | Vaccine based on Adenoviral vector |
PTX-COVID19-B | RNA | Providence Therapeutics | Vaccine based on mRNA |
SC-Ad6-1 | Viral vector (Non-replicating) | Tetherex Pharmaceuticals Corporation | Adneviral vector vaccine |
ReCOV | Protein subunit | Jiangsu Rec-Biotechnology | Recombinant two-component S and RBD protein COVID-19 vaccine (CHO cell) |
RBD protein recombinant SARS-CoV-2 vaccine | Protein subunit | Bagheiat-allah University of Medical Sciences | Recombinant RBD of the spike protein of SARS-CoV-2 |
ABNCoV2 | Virus like particle | Radboud University | ABNCoV2 capsid VLP with or without adjuvant MF59 |
GX-19N | DNA | Genexine Consortium | Vaccine expressing spike protein antigen |
EpiVacCorona | Protein subunit | Federal Budgetary Research Institution State Research Center of Virology and Biotechnology "Vector" | Peptide antigens of proteins of SARS-CoV-2, conjugated to a carrier protein and adsorbed on aluminum hydroxide as adjuvant |
Dendritic cell vaccine AV-COVID-19 | Protein subunit | Center for Genetic Engineering and Biotechnology (CIGB) | A vaccine containing autologous dendritic cells loaded with SARS-CoV-2 antigens, with or without GM-CSF |
rVSV-SARS-CoV-2-S Vaccine | Protein subunit | Center for Genetic Engineering and Biotechnology (CIGB) | Replication-competent SARS-CoV-2 spike protein |
BECOV2 | Protein subunit | Biological ELimited | Protein subunit vaccine |
GBP510 | Protein subunit | SK Bioscience Co., Ltd | A recombinant surface protein vaccine with adjuvant AS03 (aluminum hydroxide) |
COVAC-1 and COVAC-2 sub-unit vaccine | Protein subunit | University of Saskatchewan | (spike protein) + SWE adjuvant |
SARS-CoV-2-RBD-Fc fusion protein | Protein subunit | University Medical Center Groningen/Akston Biosciences Inc | Recombinant RBD with Fc fusion protein |
DS-5670a | RNA | Daiichi Sankyo Co., Ltd | mRNA vaccine |
Recombinant SARS-CoV-2 Vaccine (CHO cell) | Protein subunit | National Vaccine and Serum Institute, China | Subunit vaccine |