Fig. 1
From: Study of SV40 large T antigen nucleotide specificity for DNA unwinding
Structure of the SV40 LT nucleotide binding pocket and the various pocket mutants. a Crystal structure of the LT hexameric helicase, represented by residues 251–627 in the form of a hexamer bound to six ATP (PDBid: 1SVM). The nucleotide pocket is located at the interface between adjacent monomers as indicated with an outlined box. b A close-up of the nucleotide pocket bound to ATP and Mg++. The P-loop is colored in yellow. c, d, e Locations of the polar/charged residues c and hydrophobic residues e chosen for the mutational analysis of the binding pocket are indicated in magenta and green and their mutants are listed in d