HSV-1 clone | Mutations in vTK | Accession number | IC50 of ACV (that in the previous study [18]), (μg/ml) | LD50 (PFU/head) | ||
---|---|---|---|---|---|---|
 | Nucleotidea | Amino acida |  |  | Intracerebral inoculation | Corneal inoculation |
TAS | No | No | AB047358 | 1.2 × 100 (6.0 × 10−1) | 1.3 × 10−1 | 1.1 × 103 |
CL1 | G added within 7G (430–436) | AB047359 | 1.1 × 102 (>1.0 × 102) | 1.3 × 103 | >1.0 × 106 c | |
CL18 | C194A | Thr65Asnb | AB047372 | 5.6 × 100 (4.8 × 100) | 7.5 × 100 | 4.9 × 104 |
CL19 | C250T | Pro84Ser | AB047373 | 2.1 × 101 (1.6 × 101) | 1.0 × 100 | 1.9 × 104 |
CL22 | C734T | Thr245Met | AB047376 | 7.8 × 101 (8.0 × 101) | 1.0 × 102 | > 1.0 × 106 |
CL24 | G1007A | Cys336Tyr | AB047378 | 5.6 × 101 (7.2 × 101) | 3.2 × 101 | > 1.0 × 106 |