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Fig. 4 | Virology Journal

Fig. 4

From: Breadth and magnitude of antigen-specific antibody responses in the control of plasma viremia in simian immunodeficiency virus infected macaques

Fig. 4

Antigen-specific immunoglobulin responses to linear SIVMAC239 Envelope peptides. a Amino acid sequence of SIVMAC239 Envelope protein, indicating regions containing potential linear epitopes responsible for peptide-specific IgG, IgA, and IgM responses were shown. Bracketed regions identify the amino acid sequences used to construct 15mer 10 peptide pools (PP 1–22). Colors refer to the percentage of animals exhibiting peptide-specific immunoglobulins for that region during infection with SIVMAC251 as shown in the key. Shaded regions show the variable regions V1-5, and the arrow indicates the proteolytic cleavage site for surface protein gp120 and transmembrane protein gp41. The percentage of macaques with peptide-specific IgG (b), IgM (c) and IgA (d) responses for SIV-Env peptides are shown for SIV infected macaques inoculated either intravaginally (n = 6) or intrarectally (n = 7). Responses to individual peptide pools (PP) are shown for each time point (days post infection; dpi). Colors refer to the percentage of animals exhibiting peptide-specific immunoglobulin responses for that region during infection with SIVMAC251 as shown in the key

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Virology Journal

ISSN: 1743-422X