Table 2 Correlation of ALT and HCV RNA levels with cytokine and chemokine concentrations in ATAHC participants with detectable HCV RNA at the time of acute HCV detection (n = 117)

Cytokine	ALT		HCV RNA
Cytokine	Pearson’s correlation coefficient^a	P	Spearman’s rho^b	P
IL-1β	−0.05	0.594	−0.02	0.800
IL-2	−0.16	0.089	0.03	0.755
IL-4	0.07	0.459	−0.03	0.761
IL-6	−0.07	0.436	0.13	0.179
IL-8	0.08	0.400	0.20	0.029
IL-10	0.04	0.668	−0.07	0.460
IL-17A	−0.05	0.609	0.00	0.998
IL-17 F	−0.13	0.180	0.08	0.388
IL-18	0.02	0.848	−0.06	0.540
IL-21	0.05	0.629	0.01	0.943
IL-22	0.03	0.735	0.08	0.400
IL-25	0.01	0.921	0.05	0.629
IL-31	−0.12	0.198	−0.06	0.541
IL-33	0.00	0.982	0.00	0.973
IFN-γ	−0.01	0.904	−0.09	0.359
TNF-α	−0.03	0.780	0.11	0.240
TRAIL	−0.01	0.912	−0.15	0.118
sCD40L	0.04	0.680	0.06	0.539
Eotaxin (CCL11)	0.06	0.534	0.05	0.574
IP-10 (CXCL10)	0.43	<0.001	0.44	<0.001
MCP1 (CCL2)	0.18	0.049	0.13	0.173
MIP-1β (CCL4)	0.29	0.001	0.43	<0.001
RANTES (CCL5)	0.11	0.232	0.01	0.897
	Median (IQR)^c	P	Median (IQR)^d	P
IL-23		0.066		0.860
BLL (n = 30)	278 (109–498)		84,615 (6,538-692,308)
Quantified (n = 86)	130 (67–325)		74,380 (2,218-826,923)
IFN-γ2		0.315		0.277
BLL (n = 95)	153 (82–355)		67,308 (2,785-634,615)
Quantified (n = 21)	130 (54–385)		364,433 (8,654-1,288,462)
TNF-β		0.384		0.174
BLL (n = 111)	145 (73–423)		88,756 (2,885-826,923)
Quantified (n = 6)	125 (70–254)		11,442 (5,836-14,423)
MIP-1α (CCL3)		0.048		0.170
BLL (n = 52)	115 (54–296)		41,752 (2,732-395,529)
Quantified (n = 65)	217 (77–486)		88,756 (3,519-1,057,692)

Abbreviation: IQR inter-quartile range, BLL below lower limit of quantification
^a ALT log₁₀ IU/L, Cytokines log₁₀ pg/mL, ^b HCV RNA IU/mL, Cytokines pg/mL, ^c ALT IU/L, ^d HCV RNA IU/mL

ISSN: 1743-422X