Occult hepatitis B virus infection: influence of S protein variants

Table 3 Distribution of amino acid changes in the full-length S protein and its different regions

OBI group	No. of residue changes/100 aa^a					Control group	No. of residue changes/100 aa^a
OBI group	aa 1–226	aa 1–99	aa 100–169	aa 124–147	aa 170–226	Control group	aa 1–226	aa 1–99	aa 100–169	aa 124–147	aa 170–226
O1	2.41	2.24	0.79	1.85	4.68	C1	1.70	1.12	0.83	1.54	3.79
O2	1.37	1.01	0.75	0.44	2.77	C2	1.71	0.38	0.89	0.00	5.04
O3	1.43	1.07	0.59	0.74	3.10	C3	1.51	1.17	0.23	0.00	3.69
O4	1.92	1.57	0.79	0.69	3.90	C4	1.86	1.48	0.86	0.56	3.74
O5a	2.16	1.90	1.60	1.47	3.30	C5	1.11	0.90	0.24	0.23	2.53
O5b	1.42	1.01	0.14	0.00	3.68
O6	2.16	1.31	1.09	1.23	4.95	C6	2.47	2.02	2.86	4.17	2.77
O7	1.13	0.39	0.56	0.00	3.12	C7	2.26	2.50	1.18	2.45	3.20
O8	1.49	1.08	0.31	0.00	3.63	C8	2.29	2.13	1.19	1.16	3.90
O9	1.73	0.81	0.57	0.00	4.74	C9	1.99	0.86	2.00	2.29	3.95
O10	1.93	0.48	1.68	0.74	4.75	C10	1.77	1.01	1.02	1.49	4.01
O11	1.37	0.40	1.29	2.08	3.16	C11	1.96	0.38	1.70	1.30	5.04
O12	1.43	0.56	0.56	0.00	4.00	C12	1.62	0.67	1.81	2.22	3.04
O13a	2.21	1.11	1.64	1.04	4.82	C13	1.23	0.79	0.24	0.23	3.22
O13b	1.47	0.67	0.48	0.00	4.09
O14	1.44	0.51	0.71	0.00	3.95	C14	1.43	0.77	0.34	0.00	3.92
O15	2.96	1.55	2.86	3.21	5.53	C15	2.26	1.68	0.95	0.00	4.87
Median	1.49	1.01	0.75	0.69	3.95	Median	1.77	1.01	0.95	1.16	3.79
P-Value	0.461	0.623	0.428	0.307	0.546

aa 1–226 full-length region, aa 1–99 N-terminal region, aa 100–169 MHR antigenic loops, aa 124–147 “α” determinant, aa 170–226 C-terminal region; ^areference sequence: genotype B (GQ205440), genotype C (GQ205441)

ISSN: 1743-422X