Table 1 Genetic susceptibility
Gene | Function | Reference |
|---|---|---|
FcγRIIa | Protected from DHF | Am. J. Trop. Med. Hyg. 2002, 67(1): |
Vitamin D receptor (VDR) | Associated with resistance to severe dengue | Human Immunology. 2012, 73: 1194–1199. |
IL-10 | Associate with dengue disease severity | Plos one. 2012, 7 (11), e50387. |
TNFa | Associate with dengue disease severity | Plos one. 2012, 7 (11), e50387. |
TGFb | Associate with dengue disease severity | Plos one. 2012, 7 (11), e50387. |
JAK1 | Strongly association with DHF | Eur. J. Human Genet. 2010, 18: 1221–1227. |
HLA class I alleles A*01, A*0207, A*24, B*07, B*46, B*51 | DHF development | Clin Microbio Rev. 2009, 22 (4): 564–581., Tissue Antigens 60:309–318. |
HLA class II alleles DQ*1, DR*1, DR*4 | DHF development | Clin Microbio Rev. 2009, 22 (4): 564–581. |
Glucose-6-phosphate dehydrogenase | Increase DENV replication | Blood Cells Mol. Dis. 2009. 42:267–278. |
DC-SIGN | Associated with DENV infection | Med Sci (Paris). 2005, 21: 905–906. |
TAP | Prevent DHV/DSS | Scand J Immunol 67:618–625 |
MBL | Protect against DENV | Hum Immunol 69: 122–128. |
CTLA-4 | Increases the risk of DHF. | Clin Immunol 131: 404–409. |
MICB | Associated with severe forms of dengue | Nat Genet. 43(11): 1139–1141 |
PLCE1 | Associated with severe forms of dengue | Nat Genet. 43(11): 1139–1141 |
ABO blood group | Increases the risk of DHF | J Inf Dis 195:1014–1017 |
HPA2 | Enhance susceptibility to DHF | Hum Immunol 68:973–979 |
IFN-γ | Enhance severity of dengue disease | FEMS Immunol Med Mic 2000; 28: 183–188. |
IL-6 | Associated with DSS | PLoS Negl Trop Dis. 2013, 7(9): e2412. |
VCAM-1 | Associated with severe dengue | Trop Med Health. 2014, 42(4): 137–44. |
Oligoadenylate synthetases (OAS) | Enhance susceptibility to dengue infection | Infection, Genetics and Evolution 2013, 14: 390–395. |