Fig. 4

Amino acid sequence alignment of the N-terminal region of the S protein of global PEDV strains. The top illustration represents the organization of the PEDV genome. Only the corresponding alignment of amino acid sequences of the N-terminal region containing hypervariable regions [26] is shown. Dashes (−) indicate deleted sequences. Potential N glycosylation sites predicted by GlycoMod Tool (http://www.expasy.ch/tools/glycomod/) are shown in boldface type. Genetic subgroups of PEDV were marked with different colors: G1a (red), G1b (blue), G2a (green), and G2b (black). Insertions and deletions (indels) within PEDV isolates compared to the prototype CV777 strain are shaded. Amino acids representing potential hypervariable domains are indicated by solid boxes