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Table 4 Replication of the SW/3/06 virus in guinea pigs

From: The pathogenicity of swan derived H5N1 virus in birds and mammals and its gene analysis

Inoculation route (dose, EID50)

Mean viral titer (log10EID50/g)a

Seroconversion (positive/total)c

Nasal washb

Trachea

Lung

I.n. (104.3)

2.2 ± 0.3

1.5 ± 0.7

3.6 ± 0.9

3/3

I.m. (104.3)

–

–

1.8 ± 0.2

3/3

  1. aGroups of five guinea pigs were slightly anesthetized and inoculated intranasally or intramuscularly with 104.3 EID50 of test virus (300 μl volume, 150 μl per nostril). Virus was not detected in the spleen, kidney, colon or brain of any animal inoculated with the SW/3/06 virus; data not shown. –, virus not detected in undiluted samples.
  2. bLog10 EID50/ml.
  3. cSeroconversion was determined on 14, 21, 28 dpi by the HI assay.
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Virology Journal

ISSN: 1743-422X