From: The pathogenicity of swan derived H5N1 virus in birds and mammals and its gene analysis
Inoculation route | Dose (EID50) | Hpi | Viral titer (log10EID50/0.1 mL, mean ± standard deviation) | MLD50(EID50) | MID50(EID50) | ||||
---|---|---|---|---|---|---|---|---|---|
Lung | Brain | Liver | Spleen | Kidney | |||||
I.n. | 104.0 | 30-48 | 6.4 ± 0.7 | 1.9 ± 0.1 | 2.7 ± 0.6 | 4.2 ± 1.0 | 4.1 ± 0.8 | 2.9 | 1.7 |
I.m. | 104.0 | 48-72 | 6.2 ± 0.8 | 1.8 ± 0.1 | 2.0 ± 0.4 | 3.6 ± 0.5 | 3.5 ± 1.5 |