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Table 1 Calculated IC50 and IC90 for λ-carrageenan, cellulose sulfate, and dextran sulfate (mg/mL)

From: Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1

 

P4-R5 MAGI

Human PBMCs

 

HIV-1 BaL

HIV-1 IIIB

HIV-1 BaL

HIV-1 IIIB

 

IC50

IC90

IC50

IC90

IC50

IC90

IC50

IC90

LC

0.0037 (± 0.0009)

6.04a (± 0.79)

0.064 (± 0.0084)

1.96 (± 0.077)

0.967 (± 0.53)

3.16b (± 0.04)

0.061 (± 0.021)

0.87 (± 0.32)

CS

0.023 (± 0.0018)

1.24 (± 0.47)

0.003 (± 0.00047)

0.026 (± 0.00073)

0.0026 (± 0.0003)

0.0091 (± 0.0052)

0.014 (± 0.0034)

0.03 (± 0.0025)

DS

0.0058 (± 0.0011)

0.031 (± 0.012)

0.00052 (± 0.00011)

0.0028 (± 0.00015)

0.14 (± 0.045)

0.9 (± 0.18)

0.00056 (± 0.00017)

0.014 (± 0.0064)

  1. CS cellulose sulfate, DS dextran sulfate, IC 50 the concentration at which 50% virus inhibition is achieved, IC 90 the concentration at which 90% virus inhibition is achieved, LC λ-carrageenan, PBMCs peripheral blood mononuclear cells
  2. aExtrapolated concentration
  3. bLC concentrations > 3.16 mg/mL could not be used due to excessive solution viscosity. Because 90% inhibition of HIV-1 BaL infection by LC in PBMCs was not achieved, the LC IC75 (concentration that resulted in a 75% reduction of infection with respect to mock-treated, HIV-1-infected cells) was calculated and used in the PBMC washout experiments
  4. Presented data are from two independent experiments in which each data point was examined in triplicate
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Virology Journal

ISSN: 1743-422X