Figure 1
From: Application and removal of polyanionic microbicide compounds enhances subsequent infection by HIV-1
Polyanionic compound antiviral activity is demonstrated against both R5 and X4 HIV-1 in both P4-R5 MAGI cells and peripheral blood mononuclear cells (PBMCs). P4-R5 MAGI cells were infected for 1 h with (A) HIV-1 strain BaL (CCR5 tropic) or (B) HIV-1 strain IIIB (CXCR4 tropic) in the presence of dextran sulfate (DS), cellulose sulfate (CS), or λ-carrageenan (LC). Infectivity remaining is expressed relative to mock-treated, HIV-1-infected cells. PBMCs were incubated for 1 h with (C) HIV-1 strain BaL or (D) IIIB in the presence of DS, CS, or LC. Infectivity remaining is expressed relative to mock-treated, HIV-1-infected cells. Data for this experiment are shown as mean values and calculated standard deviations from two independent assays in which each concentration was examined in triplicate. Error bars represent standard deviations.