Figure 4

NF-κB activity is impaired upon GBP1 silencing. (A) GBP1 was silenced efficiently in 293T cells as shown in western blot. NF-κB (B) and AP1 (C) activities were measured by dual luciferase reporter assay. (The reporter activities were normalized by internal control (pRL-TK Renilla luciferase value). The mean value of activities from control cells were set to 1.0) Results are expressed as the mean + the SEM. * p < 0.05 (t- test). Representative results from at least 3 independent experiments.