From: Naturally occurring mutations to HCV protease inhibitors in treatment-naïve patients
NS3 Protease positiona | HCV variation in different genotypes (number of sequenced patients)b | ||||
---|---|---|---|---|---|
1a | 1b | 2 | 3 | 4 | |
(n = 31) | (n = 39) | (n = 30) | (n = 33) | (n = 23) | |
36 (R) | V36L c (2) e | V36 | L36 | L36 | L36 |
41 (R) | Q41 | Q41 | Q41 | Q41 | Q41 |
43 (R) | F43 | F43 | F43 | F43 | F43 |
54 (R) | T54S (2) e | T54 | T54 | T54 | T54 |
55 (R) | V55A/I (2) e | V55F (1) e | V55 | V55 | V55 |
79 (R) | D79 | D79 | E79 | D79 | D79 |
80 (R) | Q80K/L (3) e | Q80L/N (2) e | G80 | Q80 | Q80 |
109 (R) | R109 | R109 | R109 | R109 | R109 |
138 (R) | S138 | S138C (1)d | S138 | S138 | S138 |
155 (R) | R155 | R155 | R155 | R155 | R155 |
156 (R) | A156 | A156 | A156 | A156 | A156 |
158 (R) | V158 | V158 | V158M (1) e | V158 | V158 |
168 (R) | D168 | D168 | D168 | D168Q (33) e | D168E (3) e |
170 (R) | I170 | V170I (12)d | I170 | I170V (1)d | V170 |
175 (R) | L175 | M175L (1) e | L175 | L175 | L175 |
176 (R) | E176 | E176 | D176 | S176N (4)d | E176 |
71 (C) | V71 | I71V/L (5) e | V71 | A71S (1)d | V71 |
72 (C) | I72T/F (2) e | T72I/A/L (11) e | T72 | L72F (1)d | N72C (2)d |
86 (C) | P86 | Q86P (6) e | P86S (1)d | P86S (2)d | P86 |
88 (C) | P88 | P88 | P88 | P88 | P88 |