Accepted statements concerning LPS | Main articles |
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1) Plasma values of LPS reflect microbial translocation | |
2) LPS is a marker of cellular activation, and probably of T-cell activation | |
3) Plasma values of LPS in HIV-infected patients derive from gut modification, which is largely dependent on mucosal cytokines | Epple et al. [8] |
4) LPS levels generally decrease after initiation of cART, but rarely to the same values as in healthy subjects | |
Aspects of LPS that remain to be explained | |
1) Is microbial translocation a cause or a consequence of cellular activation? | |
2) Is gut disruption completely reversible after initiating cART? | |
3) Does LPS play a key role in virologically controlled patients with blunted CD4 cell gain? |