Figure 6
From: A single cidofovir treatment rescues animals at progressive stages of lethal orthopoxvirus disease
Single CDV treatment in conjunction with VACV vaccination does not impair the development of protective immunity. Mice were treated with single dose of 5, 25 or 100 mg/kg of cidofovir at day 0 (4 hours) or day 1 (24 hours) prior to vaccination with VACV-Lister by tail scarification (1X106 pfu). One group received only CDV (CDV 100 mg/kg control). 31 days post treatment mice were challenged i.n. with 70 pfu = 70 LD50 of ECTV. Morbidity (percent of initial weight ± SE) of each group is presented.