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Table 1 Concise summary of the Immunization study of yeast derived HA protein in mice and rabbits

From: Yeast expressed recombinant Hemagglutinin protein of Novel H1N1 elicits neutralising antibodies in rabbits and mice

Animal group

Sera sample

Antibody titre

HI titre#

PRNT titre#

Mice group V1

(50μg/dose/animal)

Pre Immune

<1:16

0

<16

 

2 wks post Immunisation

1:512

32

NT*

 

2 wks post booster

1:2048

32

256

Mice group V2

(10μg/dose/animal)

Pre Immune

<1:16

0

<16

 

2 wks post Immunisation

1:256

32

NT*

 

2 wks post booster

1:1024

32

64

Mice control group

Pre Immune

<1:16

0

<16

 

2 wks post Immunisation

<1:16

0

NT*

 

2 wks post booster

<1:16

0

<16

Rabbit 1 (50μg/dose/animal)

Pre Immune

<1:16

0

<16

 

2 wks post Immunisation

1:2048

32

NT*

 

2 wks post booster

1:8192

64

256

Rabbit 2 (50μg/dose/animal)

Pre Immune

<1:16

0

<16

 

2 wks post Immunisation

1:2048

32

NT*

 

2 wks post booster

1:8192

64

256

Rabbit Control

Pre Immune

<1:16

0

<16

 

2 wks post Immunisation

<1:16

0

NT*

 

2 wks post booster

<1:16

0

<16

  1. NT* - Not tested; # HI and PRNT titres are the mean reciprocals obtained against the H1N1 virus isolated during the 2009 outbreak in India