Table 3 IL-10 Gene Promoter Polymorphisms With Initial Response to IFN-α therapy in patients with HBV

Allele

n = 24 × 2 = 48

n = 28 × 2 = 56

-819C

4(8.3)

16(28.6)

0.23

0.01

-819T

44(91.6)

40(71.4)

4.4

0.01

-592C

8(16.6)

32(57.1)

0.15

<0.01

-592A

40(83.3)

24(42.9)

6.67

<0.01

-1082A

47(97.9)

53(94.6)

2.66

0.62

-1082G

1(2.1)

3(5.4)

0.38

0.62

Genotype

n = 24

n = 28

-592A/A

19(79.1)

4(14.3)

22.8

<0.01

-592A/C

2(8.3)

18(64.3)

0.05

<0.01

-592C/C

3(12.5)

6(21.4)

0.52

0.48

-819T/T

21(87.5)

15(53.6)

6.07

0.02

-819T/C

2(8.3)

10(35.7)

0.16

0.02

-819C/C

1(4.2)

3(10.7)

0.36

0.62

-1082A/A

23(95.8)

25(89.3)

2.78

0.62

-1082A/G

1(4.2)

3(10.7)

0.36

0.62

-1082G/G

0(0)

0(0)

-

-

Heplotype

n = 24

n = 28

ATA

19(79.1)

13(46.4)

4.38

0.02

GCC

0(0)

3(10.7)

-

-

ACC

5(20.8)

12(42.8)

0.35

0.14