From: HIV integrase variability and genetic barrier in antiretroviral naïve and experienced patients
IN codon position | Substitution | Wild type codon | Codon % distribution | Mutational resistance codon | Lower score | IN codon position | Substitution | Wild type codon | Codon % distribution | Mutational resistance codon | Lower scores | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
HAART-naïve (n = 41) | RTI/PI-experienced (n = 54) | HAART-naïve (n = 41) | RTI/PI-experienced (n = 54) | ||||||||||
51 | H51Y | CAT | 98 | 100 | TAT | 1 | 143 | Y143C | TAC | 90 | 90 | TGC | 1 |
CAC | 2 | 0 | TAC | 1 | TAT | 10 | 10 | TGT | 1 | ||||
66 | T66I | ACA | 98 | 94 | ATA | 1 | Y143R | TAC | 90 | 90 | CGC | 2 | |
ACC | 0 | 6 | ATC | 1 | TAT | 10 | 10 | CGT | 2 | ||||
ACG | 2 | 0 | ATA | 2 | 146 | Q146P | CAA | 98 | 98 | CCG | 2.5 | ||
72 | V72I | GTT | 32 | 31 | ATT | 1 | CAG | 2 | 2 | CCA | 2.5 | ||
GTC | 15 | 6 | ATC | 1 | Q146K | CAA | 98 | 98 | AAA | 2.5 | |||
GTA | 0 | 6 | ATA | 1 | CAG | 2 | 2 | AAG | 2.5 | ||||
GTG | 0 | 4 | ATA | 2 | 147 | S147G | AGT | 76 | 70 | GGT | 1 | ||
I72 | ATT | 41 | 45 | 0 | AGC | 24 | 30 | GGC | 2 | ||||
ATC | 12 | 2 | 0 | 148 | Q148H | CAA | 80 | 96 | CAT/C | 2.5 | |||
ATA | 0 | 4 | 0 | CAG | 20 | 4 | CAT/C | 2.5 | |||||
D72 | GAT | 0 | 2 | ATT | 3.5 | Q148K | CAA | 80 | 96 | AAA | 2.5 | ||
74 | L74I | CTG | 72 | 78 | ATA | 3.5 | CAG | 20 | 4 | AAG | 2.5 | ||
CTA | 10 | 15 | ATA | 2.5 | Q148R | CAA | 80 | 96 | CGA | 1 | |||
TTA | 10 | 2 | ATA | 2.5 | CAG | 20 | 4 | CGG | 1 | ||||
TTG | 2 | 0 | ATA | 3.5 | 151 | V151I | GTA | 71 | 72 | ATA | 1 | ||
I74 | ATT | 0 | 0 | 0 | GTG | 29 | 28 | ATA | 2 | ||||
ATA | 2 | 7 | 0 | 153 | S153Y | TCT | 76 | 87 | TAT | 2.5 | |||
M74 | ATG | 2 | 0 | ATA | 1 | TCC | 15 | 11 | TAC | 2.5 | |||
92 | E92Q | GAA | 63 | 61 | CAA | 2.5 | TCA | 7 | 2 | TAT/C | 5 | ||
GAG | 37 | 39 | CAG | 2.5 | A153 | GCC | 2 | 0 | TAC | 5 | |||
95 | Q95K | CAA | 32 | 28 | AAA | 2.5 | 155 | N155H | AAT | 90 | 93 | CAT | 2.5 |
CAG | 68 | 70 | AAG | 2.5 | AAC | 10 | 7 | CAC | 2.5 | ||||
R95 | CGG | 0 | 2 | AAG | 3.5 | N155S | AAT | 90 | 93 | AGT | 1 | ||
97 | T97A | ACA | 98 | 96 | GCA | 1 | AAC | 10 | 7 | AGC | 1 | ||
A97 | GCA | 0 | 4 | 0 | 157 | E157Q | GAA | 88 | 91 | CAA | 2.5 | ||
S97 | TCA | 2 | 0 | GCA | 2.5 | GAG | 7 | 7 | CAG | 2.5 | |||
121 | F121Y | TTC | 90 | 98 | TAC | 2.5 | Q157 | CAA | 5 | 2 | 0 | ||
TTT | 10 | 2 | TAT | 2.5 | 160 | K160D | AAA | 85 | 93 | GAT/C | 3.5 | ||
125 | T125K | ACA | 27 | 18 | AAG | 2.5 | AAG | 11 | 5 | GAT/C | 3.5 | ||
ACT | 10 | 4 | AAA/G | 5 | R160 | AGA | 2 | 0 | GAT | 4.5 | |||
ACG | 12 | 24 | AAG | 2.5 | Q160 | CAA | 2 | 2 | GAT/C | 5 | |||
A125 | GCA | 44 | 33 | AAA | 3.5 | 163 | G163R | GGA | 63 | 57 | AGA | 1 | |
GCG | 2 | 6 | AAG | 3.5 | GGG | 27 | 39 | AGG | 1 | ||||
GCT | 0 | 6 | AAA/G | 6 | GGT | 0 | 2 | CGC,AGA/G | 3.5 | ||||
V125 | GTG | 0 | 7 | AAG | 3.5 | E163 | GAA | 0 | 4 | AGA | 2 | ||
GTA | 2 | 0 | AAA | 3.5 | N163 | AAC | 0 | 2 | CGC,AGA/G | 3.5 | |||
M125 | ATG | 2 | 0 | AAG | 2.5 | A163 | GCG | 0 | 2 | CTG,AGG | 3.5 | ||
P125 | CCG | 0 | 2 | AAG | 5 | 165 | V165I | GTA | 56 | 52 | ATA | 1 | |
128 | A128T | GCA | 54 | 50 | ACA | 1 | GTC | 22 | 18 | ATC | 1 | ||
GCC | 37 | 46 | ACC | 1 | GTT | 2 | 10 | ATT | 1 | ||||
GCT | 9 | 4 | ACT | 1 | GTG | 0 | 2 | ATA | 2 | ||||
138 | E138K | GAA | 100 | 98 | AAA | 1 | I165 | ATA | 20 | 18 | 0 | ||
D138 | GAC | 0 | 2 | AAA/G | 3.5 | 201 | V201I | GTA | 24 | 28 | ATA | 1 | |
140 | G140S | GGA | 46 | 37 | AGT/C | 3.5 | GTG | 2 | 2 | ATA | 2 | ||
GGC | 44 | 46 | AGC | 1 | I201 | ATA | 74 | 70 | 0 | ||||
GGT | 5 | 6 | AGT | 1 | 203 | I203M | ATA | 95 | 98 | ATG | 1 | ||
GGG | 5 | 9 | AGT/C | 3.5 | M203 | ATG | 5 | 2 | 0 | ||||
G140A | GGA | 46 | 37 | GCA | 2.5 | 230 | S230R | AGC | 90 | 96 | AAC | 1 | |
GGC | 44 | 46 | GCC | 2.5 | N230 | AAC | 10 | 4 | 0 | ||||
GGT | 5 | 6 | GCT | 2.5 | 263 | R263K | AGA | 85 | 96 | AAA | 1 | ||
GGG | 5 | 6 | GCT/G | 2.5 | AGG | 15 | 4 | AAG | 1 |