From: HIV integrase variability and genetic barrier in antiretroviral naïve and experienced patients
Category (strain no.) | Mean nucleotide divergence ± SD | Mean amino acid divergence ± SD | IN conserved amino acid (%) | IN variable amino acid (%) | IN conserved amino acid in three functional domains (%) | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
RT gene | PR gene | IN gene | RT gene | PR gene | IN gene | Singletona | Parsimonyb | NTD (1-50) | CCD (51-212) | CTD (213-277) | ||
HAART-naïve (41) | 9.2 ± 2.3 | 10.5 ± 2.9 | 8.8 ± 2.5 | 6.3 ± 1.8 | 11.3 ± 3.5 | 7.0 ± 1.8 | 180 (65.9) | 36 (13.2) | 57 (20.9) | 26 (52.0) | 114 (70.4) | 40 (62.5) |
RT/PI-experienced (54) | 9.8 ± 2.5 | 12.2 ± 3.6 | 8.3 ± 2.5 | 9.8 ± 2.6 | 18.8 ± 7.8 | 6.5 ± 1.9 | 170 (62.3) | 39 (14.3) | 64 (23.4) | 26 (52.0) | 103 (63.6) | 41 (64.1) |
HAART-naïve vs RT/PI-experienced | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 | ns | ns | ns | ns | ns | ns |
HIV-2 (4) | ND | ND | 13.0 ± 1.1 | ND | ND | 7.9 ± 1.4 | 241(88.3) | 9(3.3) | 23 (8.4) | 39 (78.0) | 149 (91.9) | 53 (82.8) |
HIV-2 vs HIV-1 | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 | p < 0.001 |