The full genome sequence of three strains of Jamestown Canyon virus and their pathogenesis in mice or monkeys

Table 5 Jamestown Canyon virus strains are highly infectious for weanling Swiss Webster mice, are weakly neuroinvasive, and differ in neurovirulence

Virus	Neuroinvasiveness^a (log₁₀ PFU)		Neurovirulence^b (log₁₀ PFU)		Phenotype^e
	LD₅₀^c	ID₅₀^d	LD₅₀	ID₅₀	Neuroinvasive	Neurovirulent
JCV/61/CO	4.8	0.8	1.2	0.5	Low	High
JCV/61/CO-cl	> 4	0.9	0.4	0.4	Low	High
JCV/03/CT	> 5	< 0	3.7	0.3	Low	Low
JCV/03/CT-cl	> 5	< 0	> 4	-0.5	Low	Low
JCV/04/CT-cl	> 5	0.3	1.4	< -1	Low	High

^a Groups of weanling Swiss Webster mice (21-23 days old) were inoculated intraperitoneally with 100 μL of diluted virus (0 - 5 log₁₀ PFU).
^b Groups of six weanling Swiss Webster mice (21-23 days old) were inoculated intracerebrally with 10 μL of diluted virus (-1 - 4 log₁₀ PFU).
^c LD₅₀ = Lethal dose 50%.
^d ID₅₀ = Infectious dose 50%. Infection was defined by the development of clinical disease and/or a four-fold increase in neutralizing antibody titers.
^e Neuroinvasive phenotype: Low = LD₅₀ > 3.5 log₁₀ PFU. Neurovirulent phenotype: Low = LD₅₀ > 3.5 log₁₀ PFU; High = LD₅₀ < 1.5 log₁₀ PFU.

ISSN: 1743-422X