| Conservations * | Mutations | Chromatin binding | Interaction with LEDGF/p75 |
---|---|---|---|---|
Wild type | Â | Wild type | +++ | +++ |
D64/D116 | 99.4/99.7 | DD64, 116EA | +++ | ++ |
K136 | 31.3 | K136A | +++ | ++ |
K159 | 99.5 | K159P | - | +/- |
V165 | 93.5 | V165A | - | - |
E170 | 99.6 | H171A | +++ | - |
H171 | 98.5 | L172A | +++ | - |
L172 | 99.4 | EH170,1AA | ++ | - |
K173 | 96.9 | EK170,3AA | +++ | +++ |
V176 | 99.4 | HL171,2AA | - | - |
A179 | 99.8 | HK171,3AA | ++ | ++ |
I182 | 98.0 | V176A | - | - |
F185 | 99.4 | A179P | - | - |
KR186,7 | 99.7/99.0 | A179I | - | NA |
I200 | 98.3 | I182A | + | ++ |
I203 | 96.8 | F185A | + | ++ |
 | KR186,7AA | - | - | |
 | I200A | + | - | |
 | I203A | +++ | ++ | |
 | I203P | - | - |