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Table 2 Comparison of critical amino acid residues in hemagglutinin and neuraminidase proteins.

From: Avian influenza A (H9N2): computational molecular analysis and phylogenetic characterization of viral surface proteins isolated between 1997 and 2009 from the human population

 

Hemagglutinin

Neuraminidase

Viruses

Receptor Binding Site

cleavage Site

Stalk deletions

Hemadsorbing Site

drug binding pocket

 

191

198

234

235

236

335 - 338

38-39

46-50

62-64

366 - 373

399 - 404

431 - 433

118

119

151

152

277

292

371

 

H

E

L

Q

G

RSSR

   

I

K

K

D

S

R

S

G

D

S

D

I

R

S

P

Q

E

R

E

D

R

E

R

R

A/Quail/Hong Kong/G1/971

-

-

-

-

-

-

Yes

No

No

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

-

A/Duck/Hong Kong/Y280/972

-

T

-

-

-

-

No

No

Yes

-

-

E

-

-

-

-

-

-

-

-

N

W

-

-

-

-

-

-

-

-

-

-

-

A/Chicken/Beijing/1/942

-

V

Q

-

-

-

                           

A/Chicken/Hong Kong/G9/972

-

A

-

-

-

-

                           

A/Duck/Hong Kong/Y439/973

-

-

Q

-

-

A-N-

                           

A/Ck/Korea/38349-p96323/963

-

-

Q

-

-

A-Y-

No

No

No

-

S

-

-

-

-

-

-

-

N

N

N

W

-

-

-

-

-

-

-

-

-

-

-

A/Hong Kong/1074/97

-

-

-

-

-

-

Yes

No

No

-

-

-

-

-

-

A

-

-

-

-

N

W

-

-

-

-

-

-

-

-

-

-

-

A/Shantou/239/98

N

A

-

-

-

-

No

No

No

-

-

-

-

-

-

-

-

-

-

-

S

S

-

-

K

-

-

-

-

-

-

-

-

A/Shaoguan/408/98

N

A

-

-

-

-

No

No

Yes

-

-

E

-

-

-

-

-

-

-

-

N

W

-

-

-

-

-

-

-

-

-

-

-

A/Shaoguan/447/98

N

A

-

-

-

-

No

No

Yes

-

-

E

-

-

-

-

-

-

-

-

N

W

-

-

-

-

-

-

-

-

-

-

-

A/Hong Kong/1073/99a

-

-

-

-

-

-

Yes

No

No

-

-

-

-

-

-

-

-

-

-

-

N

W

-

-

-

-

-

-

-

-

-

-

-

A/Hong Kong/1074/99

-

-

-

-

-

-

Yes

No

No

-

-

-

-

-

-

-

-

-

-

-

N

W

-

-

-

-

-

-

-

-

-

-

-

A/Guangzhou/333/99

N

V

M

-

-

-

No

No

No

-

E

-

-

-

-

-

-

-

-

-

N

S

-

-

K

-

-

-

-

-

-

-

-

A/Hong Kong/2108/03

N

V

-

-

-

-

No

No

No

-

E

-

-

-

-

-

-

-

R

-

N

S

-

-

K

-

-

-

-

-

-

-

-

A/Hong Kong/3239/08

N

A

-

-

-

-

No

No

No

-

E

-

-

-

-

-

-

-

-

-

N

S

-

-

K

-

-

-

-

-

-

-

-

A/Hong Kong/33982/09b

-

D

Q

-

-

--N-

No

No

No

-

E

-

-

-

-

-

-

-

R

-

N

S

-

-

K

-

-

-

-

-

-

-

-

A/Hong Kong/35820/09

-

D

Q

-

-

--N-

No

No

No

-

E

-

-

-

-

-

-

-

R

-

N

S

-

-

K

-

-

-

-

-

-

-

-

  1. Amino acid residues were compared in the hemagglutinin receptor binding site and cleavage sites, as well as in the neuraminidase stalk region, HB site and antiviral drug binding sites of influenza A H9N2 viruses isolated during 1997-2009 from humans. Residues differences and similarities are compared with reference strains of lineages (G1-like1, Y280-like2 and Korean-like3) and vaccine strains
  2. a, b. Dashes indicate identical/conserved residues.
  3. a A(H9N2) Available vaccine virus (G1 Clade; WHO report, 2010) b A(H9N2) Proposed vaccine virus (G1 Clade; WHO report, 2010)
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