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Table 1 Nuclease resistance of REP 9, REP 9C and their non-phosphorothioated analogs

From: Amphipathic DNA polymers exhibit antiviral activity against systemic Murine Cytomegalovirus infection

   

Nuclease resistance (- = fully degraded, ++++ = fully resistant)

compound

sequence

chemistry

Phosphodiesterase II

S1 Nuclease

Bal 31

Exo I

REP 2015

N40 (degenerate)

PO

-

-

-

-

REP 9

 

PS

++

-

++++

++++

REP 2110

C40

PO

++++

++

-

-

REP 9C

 

PS

++++

++

++++

++++

  1. PO = phosphodiester, PS = phosphorothioate
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Virology Journal

ISSN: 1743-422X