Table 3 Distinct amino acid variations detected in the indicated domains of F protein in human metapneumovirus strains.
From: Genetic diversity and evolution of human metapneumovirus fusion protein over twenty years
Domain | AA positions of domain | Subgroup | |||
|---|---|---|---|---|---|
| Â | Â | A1 | A2 | B1 | B2 |
Signal peptide | 1-22 | K20Q | Â | S21N | S21N |
F2 subunit | 23-102 | Â | D72E (3) | Â | Â |
| Â | Â | E93V | E96G | Â | Â |
Cleavage site | 102-103 | S101P (2)* | Â | S101P | Â |
Fusion peptide | 103-125 | Â | T114A | Â | A115T |
Heptad repeat A | 131-172 | Â | K172R | Â | Â |
F1 subunit | 173-453 | Â | K179Q | R179K (2) | Â |
| Â | Â | Â | S232P | F196Y | Â |
| Â | Â | I248F | G239E | Â | Â |
| Â | Â | L249P (2) | G261E | Â | Â |
| Â | Â | Â | M270T | Â | Â |
| Â | Â | Â | V271I | D280G | Â |
| Â | Â | Â | C292G | I285T | Â |
| Â | Â | Â | C292W | Â | Â |
| Â | Â | E294G (4) | E294G (2) | Â | Â |
| Â | Â | Â | K296R (3) | Â | Â |
| Â | Â | Â | N298S | Â | Â |
| Â | Â | Â | Y310N | Â | Â |
| Â | Â | Â | A314T | Â | E323K |
| Â | Â | Â | I352V | Â | N358K |
| Â | Â | Â | H368N | R396W (2) | Â |
| Â | Â | Â | N404S (2) | Â | Â |
| Â | Â | Â | T419I | K438R | Â |
Heptad repeat B | 454-486 | Â | Â | D475E (2) | Â |
Transmembrane | 490-514 | I492T | I492V | I492V | Â |
| Â | Â | I514T | L507P | Â | Â |
Cytoplasmic tail | 515-539 | K519R | P520Q | P525L | P520T |