Discovery of common marburgvirus protective epitopes in a BALB/c mouse model

Table 2 Functional immunological properties from MARV epitopes

Name and Location	9-mer Sequence	% Lysis on CTL Assay^a	Adoptive Transfer % Survival^b
VP44	KNPNNGPLL	6	40
NP144	NSGIDLGDL	16	80
NP150	NTSPVAKYL	15	20
NP157	HYSPLILAL	Not done	10
GP2	ILIQGTKNL	17	50
GP3	QGTKNLPIL	20	20
GP21	LLLDPPTNI	Not done	0
GP84	TPSSTAQHL	Not done	0
GP132	LLLSIAVLI	40	100
GP133	LSIAVLIAL	Not done	20
GP134	IALSCICRI	6	40
PBS	N/A	2	10

^a% of cells lysed when compared to Triton-X-treated targets
^bSurvival after transfer of epitope-specific splenocytes and challenge with lethal PFU (~1000) of MARV, n = 10 BALB/c mice/group

ISSN: 1743-422X