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Table 1 Virus replication levels in hamster lungs

From: Reverse genetic characterization of the natural genomic deletion in SARS-Coronavirus strain Frankfurt-1 open reading frame 7b reveals an attenuating function of the 7b protein in-vitro and in-vivo

 

Virus replication (mean* of N animals)

T-test*

 

rSCV

(Virus titer, RNA concentration, N animals)

r7bΔTMD

(Virus titer, RNA concentration, N animals)

p

Day 1 p.i.

1.04 × 107 (9.00 × 106 - 1.2 × 107) PFU/g

9.86 × 108 (2.4 × 107 - 1.8 × 108) PFU/g

0.15

 

6.65 × 107 ( 1.84 × 107 - 2.4 × 108) copies/g

1.53 × 109 (9.98 × 108 - 2.2 × 109) copies/g

0.052

 

n = 2

n = 3

 

Day 3 p.i.

9.86 × 106 (8.00 × 105 - 1.20 × 108) PFU/g

1.63 × 108 (1.00 × 108 - 3.6 × 108) PFU/g

0.13

 

4.27 × 108 (1.68 × 108 - 2.1 × 109) copies/g

7.70E × 108 (7.50 × 108 - 8.10 × 108) copies/g

0.5

 

n = 3

n = 3

 
  1. * Means were determined upon logarithmic data and calculated back into linear values. Two-tailed t-tests were done on logarithmic values
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Virology Journal

ISSN: 1743-422X