Table 2 Changes within HVR1 and outside HVR1 in viral load, normalised entropy, genetic diversity and genetic distance in patients with chronic hepatitis C according to their response to pegylated α2a-interferon/ribavirin therapy
|  | Patient group | No. of patients | Time points | Interval mean weeks | Change in serum HCV RNA × 105 copy/ml | Change in Normalised Shannon Entropy (Nucleotides) | Change in Normalised Shannon Entropy (Amino Acids) | Change in genetic diversity (mean Hamming distance) | Change in genetic distance |
|---|---|---|---|---|---|---|---|---|---|
|  | SVR | 6 | E vs B | 34 ± 10 | 3.56 ± 9.01†| 0.030 ± 0.297 | -0.026 ± 0.266 | -1.15 ± 4.56 | -0.005 ± 0.025 |
|  |  | 4 | B vs w1 | 1 ± 0 | -17.21 ± 26.33†| -0.177 ± 0.329 | -0.111 ± 0.225* | -0.05 ± 4.14 | 0.002 ± 0.026 |
|  |  | 2 | B vs w2 | 2 ± 0 | -25.98 ± 30.95 | -0.001 ± 0.267 | -0.008 ± 0.257 | 1.10 ± 1.00 | -0.001 ± 0.004 |
|  |  | 2 | B vs W3/4 | 3.5 ± 0.5 | -39.47 ± 38.11 | -0.243 ± 0.064 | -0.178 ± 0.156 | -3.35 ± 1.85 | -0.027 ± 0.015 |
HVR1 | |||||||||
|  | TF | 4 | E vs B | 24 ± 0 | 83.31 ± 92.20‡ | 0.147 ± 0.063 | 0.118 ± 0.141 | 8.75 ± 4.13 | 0.018 ± 0.032 |
|  |  | 4 | B vs w1 | 1 ± 0 | -116.22 ± 125.37‡ | -0.126 ± 0.236 | -0.086 ± 0.146* | -7.63 ± 9.98 | -0.026 ± 0.036 |
|  |  | 2 | B vs W2/4 | 3 ± 1 | -49.94 ± 56.35 | -0.073 ± 0.268 | -0.049 ± 0.220 | -0.50 ± 3.70 | -0.001 ± 0.016 |
|  |  | 3 | B vs L | 5 ± 4 | -33.70 ± 48.92 | -0.336 ± 0.348 | -0.398 ± 0.172 | -15.60 ± 15.99 | -0.054 ± 0.056 |
|  | SVR | 6 | E vs B |  |  | 0.092 ± 0.232 | 0.024 ± 0.174 | 0.02 ± 0.77 | 0.002 ± 0.006 |
|  |  | 4 | B vs w1 |  |  | -0.104 ± 0.108 | -0.049 ± 0.142 | -0.45 ± 0.62 | -0.004 ± 0.005 |
|  |  | 2 | B vs w2 |  |  | 0.127 ± 0.047 | -0.003 ± 0.054 | 0.05 ± 0.05 | 0.000 ± 0.001 |
|  |  | 2 | B vs W3/4 |  |  | -0.071 ± 0.185 | -0.002 ± 0.026 | -1.35 ± 0.95 | -0.013 ± 0.010 |
Outside | |||||||||
|  | TF | 4 | E vs B |  |  | -0.089 ± 0.276 | -0.035 ± 0.223 | 0.18 ± 1.43 | -0.010 ± 0.018 |
|  |  | 4 | B vs w1 |  |  | 0.064 ± 0.274 | 0.009 ± 0.065 | 0.15 ± 0.43 | -0.005 ± 0.008 |
|  |  | 2 | B vs W2/4 |  |  | 0.106 ± 0.239 | 0.032 ± 0.049 | 0.10 ± 0.10 | 0.001 ± 0.003 |
|  |  | 3 | B vs L |  |  | -0.007 ± 0.109 | -0.049 ± 0.148 | 0.12 ± 0.48 | -0.007 ± 0.009 |