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Table 2 Titers of hMPV in hamsters after immunization and after challenge.

From: Deletion of human metapneumovirus M2-2 increases mutation frequency and attenuates growth in hamsters

Immunizing Virusa

Mean virus titer post immunizationb (log10 PFU/gm tissue +/- SE)

Mean virus titer post challengec (log10 PFU/gm tissue +/- SE)

 

NT

Lungs

NT

Lungs

wt hMPV/NL/1/00

5.9 +/- 0.3

4.6 +/- 1.4

<0.4 +/- 0.1

<0.4 +/- 0.1

rhMPV

6.0 +/- 0.6

5.1 +/- 0.5

<0.4 +/- 0.1

<0.4 +/- 0.1

rhMPV/ΔM2-2

2.3 +/- 0.6

3.3 +/- 0.4

<0.4 +/- 0.1

<0.4 +/- 0.1

placebo

ND

ND

5.6 +/- 0.6

4.5 +/- 1.5

  1. a Syrian golden hamsters, in groups of 8, were infected intranasally with 106 PFU/animal of the immunizing virus or placebo.
  2. b 4 animals per group were sacrificed on day 4 p.i.. Nasal turbinates and lungs were harvested and virus titers were determined by plaque assay.
  3. c 28 days posit immunization, 4 animals per group were challenged with 106 PFU/animal of wt hMPV/NL/1/00. 4 days post challenge, the animals were sacrificed. Nasal turbinates and lungs were harvested and virus titers were determined by plaque assay.
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Virology Journal

ISSN: 1743-422X