Mean peak challenge virus titer (log10TCID50/ml)c | Mean sum of the daily challenge virus titers (log10TCID50/ml)d | Post-challenge serum HAI titerb | ||||||
---|---|---|---|---|---|---|---|---|
Virusa | No. animals | Pre-challenge serum HAI titerb | NP swab | TL | NP swab | TL | ||
1 | HPIV1 wt | 12 | 6.7 ± 0.6 (12/12) | 0.8 ± 0.2 f | 0.7 ± 0.1 | 2.3 ± 0.2 | 2.4 ± 0.2 | 6.6 ± 0.5 |
2e | rHPIV1-CR84G | 4 | 3.8 ± 0.9 (3/4) | ≤0.5 ± 0.0 | ≤0.5 ± 0.0 | ≤2.0 ± 0.0 | ≤2.0 ± 0.0 | 4.4 ± 1.2 |
3e | rHPIV1-CR84GHNT553A | 12 | 6.0 ± 0.6 (11/12) | 0.6 ± 0.1 | 0.6 ± 0.1 | 2.1 ± 0.1 | 2.1 ± 0.1 | 7.9 ± 0.4 |
4e | rHPIV1-CΔ170 | 6 | 5.5 ± 0.4 (6/6) | ≤0.5 ± 0.0 | ≤0.5 ± 0.0 | ≤2.0 ± 0.0 | ≤2.0 ± 0.0 | 6.5 ± 0.4 |
5 | rHPIV1-LY942A | 4 | 6.3 ± 1.2 (4/4) | 1.1 ± 0.2 | 1.2 ± 0.2 | 2.7 ± 0.3 | 2.8 ± 0.3 | 8.9 ± 1.1 |
6e | rHPIV1-CR84GHNT553ALY942A | 8 | 2.0 ± 0.0 (3/8) | 0.8 ± 0.2 | 0.8 ± 0.2 | 2.6 ± 0.3 | 2.4 ± 0.3 | 3.3 ± 0.7 |
7 | rHPIV1-CR84GLΔ1710–11 | 4 | 6.1 ± 1.8 (3/4) | 3.4 ± 0.6 | 3.0 ± 0.6 | 8.4 ± 2.0 | 8.3 ± 1.3 | 6.9 ± 1.5 |
8 | rHPIV1-CR84G/Δ170HNT553ALY942A | 4 | ≤1.0 ± 0.0 (0/4) | 2.2 ± 0.2 | 1.8 ± 0.5 | 5.1 ± 0.3 | 4.3 ± 1.3 | 5.5 ± 1.6 |
9 | rHPIV1-CR84G/Δ170HNT553ALΔ1710–11 | 4 | ≤1.0 ± 0.0 (0/4) | 4.5 ± 0.9 | 3.4 ± 0.4 | 11.8 ± 2.5 | 8.1 ± 1.3 | 7.5 ± 1.4 |
10 | Non-immune | 7 | ≤1.0 ± 0.0 (0/4) | 5.0 ± 0.6 | 3.9 ± 0.5 | 14.8 ± 1.2 | 11.0 ± 2.5 | 6.0 ± 1.3 |