Mean peak virus titer (log10 TCID50/ml)c | Mean sum of the daily virus titers (log10 TCID50/ml)d | att e | |||||||
---|---|---|---|---|---|---|---|---|---|
Virusa | Shut-off temperatureb | No. of animals | NP swabf | TLg | NP swabf | TLg | URT | LRT | |
1 | HPIV1 wt | - | 14 | 4.2 ± 0.2 | 3.9 ± 0.3 | 26.4 ± 1.5 | 12.2 ± 1.6 | - | - |
2h | rHPIV1-CR84G | - | 4 | 3.6 ± 0.4 | 4.0 ± 0.5 | 21.0 ± 1.7 | 11.7 ± 2.5 | No | No |
3h | rHPIV1-CR84GHNT553A | - | 12 | 2.1 ± 0.2 i | 4.8 ± 0.3 | 10.5 ± 0.9 | 14.3 ± 1.1 | Yes | No |
4h | rHPIV1-CΔ170 | - | 6 | 3.4 ± 0.5 | 2.3 ± 0.5 | 14.8 ± 1.9 | 5.1 ± 0.8 | Yes | Yes |
5 | rHPIV1-LY942A | 37°C | 4 | 2.3 ± 0.1 | 2.3 ± 0.2 | 16.9 ± 0.7 | 8.4 ± 1.2 | Yes | Yes |
6h | rHPIV1-CR84GHNT553ALY942A | 37°C | 8 | 2.4 ± 0.2 | 2.1 ± 0.3 | 12.9 ± 1.0 | 5.1 ± 0.6 | Yes | Yes |
7 | rHPIV1-CR84GLΔ1710–11 | 36°C | 4 | 1.5 ± 0.4 | 0.9 ± 0.2 | 8.6 ± 1.8 | 3.2 ± 0.6 | Yes | Yes |
8 | rHPIV1-CR84G/Δ170HNT553ALY942A | 38°C | 4 | 1.2 ± 0.3 | 0.6 ± 0.1 | 5.9 ± 0.5 | 2.6 ± 0.1 | Yes | Yes |
9 | rHPIV1-CR84G/Δ170HNT553ALΔ1710–11 | 35°C | 4 | 0.9 ± 0.3 | ≤0.5 ± 0.0 | 6.3 ± 0.5 | ≤2.5 ± 0.0 | Yes | Yes |