Genome sequence analysis of La Crosse virus and in vitro and in vivo phenotypes

Table 1 Passage history and geographic location of isolation/infection of the LACV isolates for which complete genomic sequences are available.

Virus	Location	Passage history^a	GenBank Accession number
LACV/human/1960	Minnesota	C6/36 2	EF485030–EF485032
LACV/human/1960-clone	Minnesota	C6/36 2, Vero 4	NA^b
LACV/mosquito/1978	North Carolina	Mouse brain 1, Vero 3	EF485036–EF485038
LACV/mosquito/1978-clone	North Carolina	Mouse brain 1, Vero 7	NA
LACV/human/1978	Wisconsin	Mouse brain 1, BHK 2, Vero 1	EF485033–EF485035
LACV/human/1978-clone	Wisconsin	Mouse brain 1, BHK 2, Vero 5	NA
LACV/mosquito/1977	Wisconsin	Unknown	DQ196118–DQ196120^c
LACV/human/1978	Wisconsin	Mouse brain 1, BHK 2	NC_004108–NC_004110^d

^aCell/tissue type followed by number of passages.
^bSequence not submitted. Genetic comparisons with uncloned parental wild-type stocks found in Table 3.
^cPrevious submission by Cheng et al. 2005.
^dPrevious submission by Hughes et al. 2002. Sequence from a derivative of this virus (one additional passage in Vero cells) was generated for this study (EF485033–EF485035) and used for subsequent comparisons since several differences with this sequence were identified.

ISSN: 1743-422X